diff --git a/components/cascader/__tests__/index.test.tsx b/components/cascader/__tests__/index.test.tsx
index 77cdcdfafd..aada06b0dd 100644
--- a/components/cascader/__tests__/index.test.tsx
+++ b/components/cascader/__tests__/index.test.tsx
@@ -1,4 +1,5 @@
 import React from 'react';
+import { Button, Input, Space } from 'antd';
 import type { SingleValueType } from 'rc-cascader/lib/Cascader';
 
 import type { DefaultOptionType } from '..';
@@ -803,4 +804,41 @@ describe('Cascader', () => {
 
     errSpy.mockRestore();
   });
+
+  it('Cascader ContextIsolator', () => {
+    const { container } = render(
+      <Space.Compact>
+        <Cascader
+          open
+          style={{ width: 120 }}
+          popupRender={(menu) => {
+            return (
+              <div>
+                {menu}
+                <Button>123</Button>
+                <Input style={{ width: 50 }} />
+              </div>
+            );
+          }}
+          options={[
+            { value: 'jack', label: 'Jack' },
+            { value: 'lucy', label: 'Lucy' },
+          ]}
+        />
+        <Button className="test-button">test</Button>
+      </Space.Compact>,
+    );
+
+    const compactButton = container.querySelector('.test-button');
+    const popupElement = document.querySelector('.ant-select-dropdown');
+    // selector should have compact
+    expect(compactButton).toBeInTheDocument();
+    expect(compactButton!.className.includes('compact')).toBeTruthy();
+    // popupRender element haven't compact
+    expect(popupElement).toBeInTheDocument();
+    const button = popupElement!.querySelector('button');
+    const input = popupElement!.querySelector('input');
+    expect(button!.className.includes('compact')).toBeFalsy();
+    expect(input!.className.includes('compact')).toBeFalsy();
+  });
 });
diff --git a/components/cascader/index.tsx b/components/cascader/index.tsx
index 281713f24e..e5bcbaa36b 100644
--- a/components/cascader/index.tsx
+++ b/components/cascader/index.tsx
@@ -31,6 +31,7 @@ import useVariant from '../form/hooks/useVariants';
 import mergedBuiltinPlacements from '../select/mergedBuiltinPlacements';
 import useSelectStyle from '../select/style';
 import useIcons from '../select/useIcons';
+import usePopupRender from '../select/usePopupRender';
 import useShowArrow from '../select/useShowArrow';
 import { useCompactItemContext } from '../space/Compact';
 import useBase from './hooks/useBase';
@@ -292,7 +293,8 @@ const Cascader = React.forwardRef<CascaderRef, CascaderProps<any>>((props, ref)
     cssVarCls,
   );
 
-  const mergedPopupRender = popupRender || dropdownRender;
+  const mergedPopupRender = usePopupRender(popupRender || dropdownRender);
+
   const mergedPopupMenuColumnStyle = popupMenuColumnStyle || dropdownMenuColumnStyle;
   const mergedOnOpenChange = onOpenChange || onDropdownVisibleChange;
   const mergedPopupStyle = styles?.popup?.root || contextStyles.popup?.root || dropdownStyle;
diff --git a/components/select/__tests__/index.test.tsx b/components/select/__tests__/index.test.tsx
index 2f7ece51e7..921cf335ad 100644
--- a/components/select/__tests__/index.test.tsx
+++ b/components/select/__tests__/index.test.tsx
@@ -1,14 +1,15 @@
 import React from 'react';
 import { CloseOutlined } from '@ant-design/icons';
+import { Button, Input, Space } from 'antd';
 
 import type { SelectProps } from '..';
 import Select from '..';
-import Form from '../../form';
 import { resetWarned } from '../../_util/warning';
 import focusTest from '../../../tests/shared/focusTest';
 import mountTest from '../../../tests/shared/mountTest';
 import rtlTest from '../../../tests/shared/rtlTest';
 import { act, fireEvent, render } from '../../../tests/utils';
+import Form from '../../form';
 
 const { Option } = Select;
 
@@ -290,4 +291,42 @@ describe('Select', () => {
       errSpy.mockRestore();
     });
   });
+
+  it('Select ContextIsolator', () => {
+    const { container } = render(
+      <Space.Compact>
+        <Select
+          open
+          defaultValue="lucy"
+          style={{ width: 120 }}
+          popupRender={(menu) => {
+            return (
+              <div>
+                {menu}
+                <Button>123</Button>
+                <Input style={{ width: 50 }} />
+              </div>
+            );
+          }}
+          options={[
+            { value: 'jack', label: 'Jack' },
+            { value: 'lucy', label: 'Lucy' },
+          ]}
+        />
+        <Button className="test-button">test</Button>
+      </Space.Compact>,
+    );
+
+    const compactButton = container.querySelector('.test-button');
+    const popupElement = document.querySelector('.ant-select-dropdown');
+    // selector should have compact
+    expect(compactButton).toBeInTheDocument();
+    expect(compactButton!.className.includes('compact')).toBeTruthy();
+    // popupRender element haven't compact
+    expect(popupElement).toBeInTheDocument();
+    const button = popupElement!.querySelector('button');
+    const input = popupElement!.querySelector('input');
+    expect(button!.className.includes('compact')).toBeFalsy();
+    expect(input!.className.includes('compact')).toBeFalsy();
+  });
 });
diff --git a/components/select/index.tsx b/components/select/index.tsx
index c69049cef1..8614293704 100755
--- a/components/select/index.tsx
+++ b/components/select/index.tsx
@@ -29,6 +29,7 @@ import { useToken } from '../theme/internal';
 import mergedBuiltinPlacements from './mergedBuiltinPlacements';
 import useStyle from './style';
 import useIcons from './useIcons';
+import usePopupRender from './usePopupRender';
 import useShowArrow from './useShowArrow';
 
 type RawValue = string | number;
@@ -203,7 +204,9 @@ const InternalSelect = <
     popupMatchSelectWidth ?? dropdownMatchSelectWidth ?? contextPopupMatchSelectWidth;
 
   const mergedPopupStyle = styles?.popup?.root || contextStyles.popup?.root || dropdownStyle;
-  const mergedPopupRender = popupRender || dropdownRender;
+
+  const mergedPopupRender = usePopupRender(popupRender || dropdownRender);
+
   const mergedOnOpenChange = onOpenChange || onDropdownVisibleChange;
 
   // ===================== Form Status =====================
diff --git a/components/select/usePopupRender.tsx b/components/select/usePopupRender.tsx
new file mode 100644
index 0000000000..e3a24086cb
--- /dev/null
+++ b/components/select/usePopupRender.tsx
@@ -0,0 +1,18 @@
+import React from 'react';
+
+import ContextIsolator from '../_util/ContextIsolator';
+
+type RenderFunction<T extends any[]> = (...args: T) => React.ReactNode;
+
+function usePopupRender<T extends [React.ReactElement, ...any[]]>(
+  renderFn?: RenderFunction<T>,
+): ((...args: T) => React.ReactElement) | undefined {
+  return React.useMemo(() => {
+    if (!renderFn) {
+      return undefined;
+    }
+    return (...args: T) => <ContextIsolator space>{renderFn(...args)}</ContextIsolator>;
+  }, [renderFn]);
+}
+
+export default usePopupRender;
diff --git a/components/tree-select/__tests__/index.test.tsx b/components/tree-select/__tests__/index.test.tsx
index 3fc73b042a..d477f777ad 100644
--- a/components/tree-select/__tests__/index.test.tsx
+++ b/components/tree-select/__tests__/index.test.tsx
@@ -1,11 +1,12 @@
 import React from 'react';
+import { Button, Input, Space } from 'antd';
 
 import TreeSelect, { TreeNode } from '..';
 import { resetWarned } from '../../_util/warning';
 import focusTest from '../../../tests/shared/focusTest';
 import mountTest from '../../../tests/shared/mountTest';
 import rtlTest from '../../../tests/shared/rtlTest';
-import { render, fireEvent } from '../../../tests/utils';
+import { fireEvent, render } from '../../../tests/utils';
 
 describe('TreeSelect', () => {
   focusTest(TreeSelect, { refFocus: true });
@@ -162,4 +163,41 @@ describe('TreeSelect', () => {
 
     errSpy.mockRestore();
   });
+
+  it('TreeSelect ContextIsolator', () => {
+    const { container } = render(
+      <Space.Compact>
+        <TreeSelect
+          open
+          defaultValue="lucy"
+          style={{ width: 120 }}
+          popupRender={(menu) => {
+            return (
+              <div>
+                {menu}
+                <Button>123</Button>
+                <Input style={{ width: 50 }} />
+              </div>
+            );
+          }}
+          treeData={[
+            { value: 'jack', title: 'Jack', children: [{ value: 'Emily', title: 'Emily' }] },
+            { value: 'lucy', title: 'Lucy' },
+          ]}
+        />
+        <Button className="test-button">test</Button>
+      </Space.Compact>,
+    );
+    const compactButton = container.querySelector('.test-button');
+    const popupElement = document.querySelector('.ant-select-dropdown');
+    // selector should have compact
+    expect(compactButton).toBeInTheDocument();
+    expect(compactButton!.className.includes('compact')).toBeTruthy();
+    // popupRender element haven't compact
+    expect(popupElement).toBeInTheDocument();
+    const button = popupElement!.querySelector('button');
+    const input = popupElement!.querySelector('input');
+    expect(button!.className.includes('compact')).toBeFalsy();
+    expect(input!.className.includes('compact')).toBeFalsy();
+  });
 });
diff --git a/components/tree-select/index.tsx b/components/tree-select/index.tsx
index 99fbc85814..d825cb28c1 100644
--- a/components/tree-select/index.tsx
+++ b/components/tree-select/index.tsx
@@ -16,6 +16,7 @@ import { getMergedStatus, getStatusClassNames } from '../_util/statusUtils';
 import { devUseWarning } from '../_util/warning';
 import { ConfigContext } from '../config-provider';
 import type { Variant } from '../config-provider';
+import { useComponentConfig } from '../config-provider/context';
 import DefaultRenderEmpty from '../config-provider/defaultRenderEmpty';
 import DisabledContext from '../config-provider/DisabledContext';
 import useCSSVarCls from '../config-provider/hooks/useCSSVarCls';
@@ -26,6 +27,7 @@ import useVariant from '../form/hooks/useVariants';
 import mergedBuiltinPlacements from '../select/mergedBuiltinPlacements';
 import useSelectStyle from '../select/style';
 import useIcons from '../select/useIcons';
+import usePopupRender from '../select/usePopupRender';
 import useShowArrow from '../select/useShowArrow';
 import { useCompactItemContext } from '../space/Compact';
 import { useToken } from '../theme/internal';
@@ -33,7 +35,6 @@ import type { AntTreeNodeProps, TreeProps } from '../tree';
 import type { SwitcherIcon } from '../tree/Tree';
 import SwitcherIconCom from '../tree/utils/iconUtil';
 import useStyle from './style';
-import { useComponentConfig } from '../config-provider/context';
 
 type RawValue = string | number;
 
@@ -226,7 +227,9 @@ const InternalTreeSelect = <ValueType = any, OptionType extends DataNode = DataN
   );
 
   const mergedPopupStyle = styles?.popup?.root || contextStyles?.popup?.root || dropdownStyle;
-  const mergedPopupRender = popupRender || dropdownRender;
+
+  const mergedPopupRender = usePopupRender(popupRender || dropdownRender);
+
   const mergedOnOpenChange = onOpenChange || onDropdownVisibleChange;
 
   const isMultiple = !!(treeCheckable || multiple);